Provigil effect on sleepiness
Methods
Twenty sleepy patients with OSAS under CPAP treatment were selected. All of them had Epworth Sleepiness Scale (ESS) > 10. Following baseline evaluation (T1), all subjects were instructed to take placebo for 7 days. After this single-blind placebo phase and second evaluation (T2), patients were randomly allocated to placebo or Provigil treatment for 21 days in a double-blind protocol.
Provigil and sleepiness
In general, sleep loss will result in performance deficits, including increased variability in performance, slowed physical and mental reaction time, increased errors, decreased vigilance, impaired memory, and reduced motivation and laxity.
There is no consensus on the extent of impairment resulting from a given amount of sleep loss.
Depending on the performance task measured, after 17-19 h of sustained wakefulness, decrements in task performance are equivalent to, or worse than, those seen at a blood alcohol concentration of 0.05%,(40) and about 20-25 h of wakefulness will result in performance decrements equivalent to a blood alcohol concentration of 0.10% on some tasks. Generally, complex performance tasks seem to be more sensitive to the effects of sleep loss than simpler tasks. It is of interest to note that the legal blood alcohol concentration limit for driving in the UK, USA, and Canada is 0.08%, in Australia is 0.05%, and in Sweden is 0.02%.
Provigil – How it Works
“It works in a very select area of the brain called the hypothalamus, which regulates among other things sleep and wakefulness,” Wyatt said.
“And because it doesn’t work in widespread areas of the brain, it seems to have a much cleaner side-effect profile, not producing nervousness or tremulousness or shakiness that other stimulants can.”
There are some side effects, including headaches, nausea, infection, possible nervousness, anxiety and insomnia. But patients would see a limited number of those effects at one time, and they are actually less than the effects of caffeine.
Wakefulness becomes easy with Provigil
Dexedrine has been the standard treatment for narcolepsy, and it has had military applications as well: the United States Air Force supplied it to most air crews during the Persian Gulf War…
Dexedrine interferes with normal sleep, leaving its users feeling hung over when they awaken. This so-called sleep inertia often prompts the user to take more pills, and a vicious cycle ensues. Provigil preserves normal “sleep architecture.”…